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Understanding Controls

This Medical Laboratory Science lesson in Molecular Diagnostics supports laboratory science learning and laboratory interpretation for medical laboratory students and professionals.

Identify positive, negative, and internal/extraction controls used in molecular testing, what each one protects against, and when a run or specimen must be called invalid.

Foundational8 min read15 sectionsMolecular Diagnostics
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Learning Objectives

Getting started

Section 1 of 15

Learning Objectives

Learning Objectives

Section: Learning Objectives

Each objective is a clinical-laboratory skill, not a molecular biology research goal.

  • Identify the purpose of positive, negative, and internal/extraction controls used in molecular testing
  • State what each control type protects against, reagent/system failure, contamination, or inhibition/extraction failure
  • Recognize when a control result requires a run or specimen to be called invalid rather than reported

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