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AHG Crossmatch

This Medical Laboratory Science lesson in Blood Bank supports laboratory science learning and laboratory interpretation for medical laboratory students and professionals.

Perform the antihuman globulin (AHG) crossmatch for a patient with a current or historical clinically significant antibody, interpret incompatibility at each phase, and validate every negative AHG-phase tube with the check-cell control before a unit can be considered serologically compatible.

Intermediate30 min read15 sectionsBlood Bank
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Learning Objectives

Getting started

Section 1 of 15

Learning Objectives

Learning Objectives

Section: Learning Objectives

Each objective below describes a transfusion-service laboratory competency, from sample receipt through compatibility testing to documented blood issue.

  • Identify when a current antibody screen result or a documented antibody history requires an AHG crossmatch rather than an immediate-spin or electronic crossmatch
  • Read and interpret crossmatch reactions at the immediate-spin, 37°C, and AHG phases, distinguishing true incompatibility from a resolvable technical issue
  • Apply the check-cell control to validate every negative AHG-phase crossmatch tube before a unit can be considered compatible

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