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Mechanisms of Resistance

This Medical Laboratory Science lesson in Medical Microbiology supports laboratory science learning and laboratory interpretation for medical laboratory students and professionals.

Connect resistance mechanisms (enzymes, efflux, porin loss, target change) to AST phenotype clues used in the laboratory.

Advanced26 min read15 sectionsMedical Microbiology
Section 1 of 150%

Learning Objectives

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Section 1 of 15

Learning Objectives

Learning Objectives

Section: Learning Objectives

Each objective describes an AST bench competency, method, QC, and category assignment, not antimicrobial selection or dosing.

  • Classify major resistance mechanisms (enzymatic inactivation, efflux, porin loss, target modification/protection) as laboratory phenotype drivers
  • Recognize when AST patterns suggest a resistance mechanism that may need confirmatory or specialized testing per SOP
  • Separate true resistance phenotypes from inoculum, media, reading, and QC artifacts before escalating mechanism hypotheses

Section 1 of 15