ABO Blood Group System

This Medical Laboratory Science lesson in Blood Bank supports laboratory science learning and laboratory interpretation for medical laboratory students and professionals.

ABO antigens A, B, and H; naturally occurring anti-A and anti-B; Landsteiner’s law; and why ABO mismatch is the highest-risk routine compatibility failure.

Foundational32 min read15 sectionsBlood Bank
Section 1 of 150%

Learning Objectives

Getting started

Section 1 of 15

Learning Objectives

Learning Objectives

Section: Learning Objectives

Each objective below describes a competency you will apply at the immunohematology bench, interpretation first, memorization second.

  • Map ABO phenotypes (A, B, AB, O) to expected red-cell antigens and plasma antibodies using Landsteiner’s law
  • Explain the roles of A, B, and H antigens in forward typing logic and why reverse typing must correlate before a group is released
  • State why ABO-incompatible RBC transfusion is clinically catastrophic and how the laboratory prevents issue through forward/reverse concordance and SOP-guided discrepancy workup