Overview
Immature erythrocytes reflecting recent marrow erythropoietic output.
Classification
| Context | Reticulocyte pattern | Interpretation frame |
|---|---|---|
| Anemia + elevated absolute retic | Marrow responding | Hemolysis, hemorrhage recovery among associations |
| Anemia + low absolute retic | Hypoproliferative | Marrow failure, nutrient deficiency, EPO lack among associations |
| Normal Hb + elevated retic | Compensated or early | Subclinical hemolysis, recovery, artifact, correlate |
Morphologic Features
Polychromasia on Wright-Giemsa correlates with reticulocytosis.
Laboratory Characteristics
- Automated reticulocyte channels, read report units
Reference Intervals
Report-specific, age and method dependent.
Clinical and Laboratory Significance
Mechanism split in anemia workup, not standalone diagnosis.
Differential Considerations
Apply correction per institutional SOP when Hct reduced.
Comparison Tables
Classification Frameworks
Laboratory Notes
- Module 3 reticulocyte-count: staining and counting methodology.
References
Authoritative textbooks, guidelines, and reviews supporting this reference entry. Verify reference intervals, critical limits, and reflex criteria against institutional protocols and current guideline editions.
Textbooks
- McPherson RA, Pincus MR. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Elsevier; 2021.
- Rodak BF, Carr JH. Rodak's Hematology: Clinical Principles and Applications. 6th ed. Elsevier; 2020.
- McKenzie SB, Williams JL. Clinical Laboratory Hematology. 4th ed. Pearson; 2022.
- Bain BJ. Blood Cells: A Practical Guide. 5th ed. Wiley-Blackwell; 2015.
CLSI and Professional Guidelines
- Clinical and Laboratory Standards Institute. Reference and Selected Performance Standards for the Automated Complete Blood Cell Count (CBC). CLSI document H26-A2. CLSI; 2010.
- Clinical and Laboratory Standards Institute. Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory; Approved Standard. CLSI document EP28-A3c. CLSI; 2010.
- Clinical and Laboratory Standards Institute. Management of Critical- and Significant-Risk Results. CLSI guideline GP47-Ed1. CLSI; 2015.
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