Overview
Reference morphology before reporting variants.
Classification
| Feature | Normal |
|---|---|
| Diameter | Similar within field |
| Pallor | ~1/3 central |
| Inclusions | None in health |
Morphologic Features
Scan monolayer systematically, avoid thick areas where cells appear smaller and darker.
Laboratory Characteristics
- Correlate with MCV/MCHC when available
Reference Intervals
Numeric intervals on report, morphology is qualitative benchmark.
Clinical and Laboratory Significance
Normal smear does not exclude all pathology, integrate indices.
Differential Considerations
Comparison Tables
Classification Frameworks
Laboratory Notes
References
Authoritative textbooks, guidelines, and reviews supporting this reference entry. Verify reference intervals, critical limits, and reflex criteria against institutional protocols and current guideline editions.
Textbooks
- McPherson RA, Pincus MR. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Elsevier; 2021.
- Rodak BF, Carr JH. Rodak's Hematology: Clinical Principles and Applications. 6th ed. Elsevier; 2020.
- McKenzie SB, Williams JL. Clinical Laboratory Hematology. 4th ed. Pearson; 2022.
- Bain BJ. Blood Cells: A Practical Guide. 5th ed. Wiley-Blackwell; 2015.
CLSI and Professional Guidelines
- Clinical and Laboratory Standards Institute. Reference and Selected Performance Standards for the Automated Complete Blood Cell Count (CBC). CLSI document H26-A2. CLSI; 2010.
- Clinical and Laboratory Standards Institute. Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory; Approved Standard. CLSI document EP28-A3c. CLSI; 2010.
- Clinical and Laboratory Standards Institute. Management of Critical- and Significant-Risk Results. CLSI guideline GP47-Ed1. CLSI; 2015.
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