Overview
Average platelet volume reported on automated CBC where available.
Classification
| Context | MPV pattern | Frame |
|---|---|---|
| Thrombocytopenia + high MPV | Large/young platelets | Peripheral consumption or recovery among associations |
| Thrombocytopenia + low MPV | Small platelets | Hypoproduction among associations |
| Storage effect | Rising MPV over time | Reanalyze within stability window |
Morphologic Features
Giant platelets on smear may elevate MPV while lowering count.
Laboratory Characteristics
- Platform-specific MPV derivation, read manufacturer limitations
Reference Intervals
Report-specific intervals.
Clinical and Laboratory Significance
Pattern support with count, not standalone etiology.
Differential Considerations
Comparison Tables
Classification Frameworks
Laboratory Notes
- Serial trends preferred over single value.
References
Authoritative textbooks, guidelines, and reviews supporting this reference entry. Verify reference intervals, critical limits, and reflex criteria against institutional protocols and current guideline editions.
Textbooks
- McPherson RA, Pincus MR. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Elsevier; 2021.
- Rodak BF, Carr JH. Rodak's Hematology: Clinical Principles and Applications. 6th ed. Elsevier; 2020.
- McKenzie SB, Williams JL. Clinical Laboratory Hematology. 4th ed. Pearson; 2022.
- Bain BJ. Blood Cells: A Practical Guide. 5th ed. Wiley-Blackwell; 2015.
CLSI and Professional Guidelines
- Clinical and Laboratory Standards Institute. Reference and Selected Performance Standards for the Automated Complete Blood Cell Count (CBC). CLSI document H26-A2. CLSI; 2010.
- Clinical and Laboratory Standards Institute. Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory; Approved Standard. CLSI document EP28-A3c. CLSI; 2010.
- Clinical and Laboratory Standards Institute. Management of Critical- and Significant-Risk Results. CLSI guideline GP47-Ed1. CLSI; 2015.
- Clinical and Laboratory Standards Institute. Collection, Transport, and Processing of Blood Specimens for Testing Plasma-Based Coagulation Assays and Molecular Hemostasis Assays; Approved Guideline. CLSI document H21-A5. CLSI; 2017.
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