Overview
Calibration sets or adjusts how an instrument converts signal into results using calibrators. Quality control checks that the testing system still produces trustworthy results using control materials. They are related but not interchangeable.
Classification
| Job | Material | Question answered |
|---|---|---|
| Calibration | Calibrators | Is the instrument response set correctly? |
| Quality control | Controls | Are today's results still trustworthy? |
Morphologic Features
Not applicable, this entry covers calibration vs QC, not morphology.
Laboratory Characteristics
- SOP defines when each is required
- After calibration, QC confirmation is commonly required
- Wrong material for the job invalidates the procedure
Reference Intervals
Not a patient reference interval. Calibrator assigned values and QC targets/limits are method- and SOP-specific.
Clinical and Laboratory Significance
Confusing calibration with QC can cause skipped checks and unreliable patient results.
Differential Considerations
Not a disease differential. If performance is wrong, ask whether the issue is an unset/incorrect calibration, a failed QC check, or both, then follow the matching SOP path.
Comparison Tables
Calibration vs QC checkpoints
| Statement | True? | Why |
|---|---|---|
| Calibration replaces QC | No | Setting response ≠ checking today's trustworthiness |
| QC replaces calibration | No | Passing controls does not set the calibrator relationship |
| Both may be needed the same day | Yes | Event-driven calibration plus routine QC per SOP |
Classification Frameworks
Not applicable . WHO disease classifications do not define calibration vs QC.
Laboratory Notes
- Calibrate = set/adjust
- QC = check trustworthiness
- Neither replaces the other
References
Authoritative textbooks, guidelines, and reviews supporting this reference entry. Verify reference intervals, critical limits, and reflex criteria against institutional protocols and current guideline editions.
Textbooks
- McPherson RA, Pincus MR. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Elsevier; 2021. (Laboratory quality and management chapters, verify current edition.)
CLSI and Professional Guidelines
- Institutional laboratory SOPs, locally adopted quality policies, and manufacturer instructions for use (IFU). Always verify current local practice.
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