Overview
Standard coagulation specimen requirements for plasma-based assays.
Classification
| Issue | Effect | Action |
|---|---|---|
| Underfilled tube | Excessive anticoagulant dilution | Reject and recollect |
| Clotted specimen | Consumed factors | Reject |
| High Hct (>55% approx.) | Citrate-to-plasma imbalance | Alternate collection per institutional SOP, do not invent formulas |
| Hemolysis | May interfere select assays | Reject or comment per SOP |
| Delayed processing | Factor degradation | Centrifuge within institutional time limit |
| Wrong tube (EDTA/heparin) | Invalid for coagulation | Reject |
Morphologic Features
Laboratory Characteristics
- Platelet-poor plasma required, double spin per protocol if needed
Reference Intervals
Not applicable, qualitative specimen standards.
Clinical and Laboratory Significance
Invalid specimen invalidates all coagulation interpretation.
Differential Considerations
Comparison Tables
Classification Frameworks
Laboratory Notes
- Verify CLSI H21 specimen handling guidance and the local coagulation SOP before release.
References
Authoritative textbooks, guidelines, and reviews supporting this reference entry. Verify reference intervals, critical limits, and reflex criteria against institutional protocols and current guideline editions.
Textbooks
- McPherson RA, Pincus MR. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Elsevier; 2021.
- Rodak BF, Carr JH. Rodak's Hematology: Clinical Principles and Applications. 6th ed. Elsevier; 2020.
- McKenzie SB, Williams JL. Clinical Laboratory Hematology. 4th ed. Pearson; 2022.
CLSI and Professional Guidelines
- Clinical and Laboratory Standards Institute. Collection, Transport, and Processing of Blood Specimens for Testing Plasma-Based Coagulation Assays and Molecular Hemostasis Assays. CLSI document H21-A5. CLSI; 2008.
- Clinical and Laboratory Standards Institute. Collection, Transport, and Processing of Blood Specimens for Testing Plasma-Based Coagulation Assays. CLSI document H21. CLSI.
- Clinical and Laboratory Standards Institute. Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory; Approved Standard. CLSI document EP28-A3c. CLSI; 2010.
- Clinical and Laboratory Standards Institute. Management of Critical- and Significant-Risk Results. CLSI guideline GP47-Ed1. CLSI; 2015.
- International Society on Thrombosis and Haemostasis. Guidelines for the diagnosis of von Willebrand disease. ISTH; 2021.
WHO Publications
- World Health Organization. Haemophilia: diagnosis and management. WHO; 2020.
Frequently Asked Questions
Common questions about using this Citrated Plasma for Coagulation Testing specimens Medical Laboratory Library reference in Medical Laboratory Science education.
What is the Citrated Plasma for Coagulation Testing laboratory reference?
Citrated Plasma for Coagulation Testing is a Specimens entry in the LabPedia Medical Laboratory Library, written for Medical Laboratory Science reference lookup.
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