Overview
Framework for laboratory pattern comments before confirmatory studies.
Classification
| Feature | Reactive pattern | Concerning pattern |
|---|---|---|
| Morphology | Toxic changes, atypical lymphocytes | Dysplasia, blasts, abnormal monocytes |
| Counts | Stress leukocytosis resolving | Persistent unexplained leukocytosis/cytopenias |
| Comment | Pattern consistent with reactive process | Morphology suggests hematology correlation |
Morphologic Features
Smear is central to branch selection.
Laboratory Characteristics
- Trend serial CBCs
- Escalate per institutional protocol
Reference Intervals
Not applicable.
Clinical and Laboratory Significance
Laboratory frames workup, clinician orders confirmatory testing.
Differential Considerations
See cell-line lessons for lineage-specific benchmarks.
Comparison Tables
Classification Frameworks
WHO classification applies after diagnostic confirmation.
Laboratory Notes
- Never imply medically reviewed malignancy diagnosis from CBC alone.
References
Authoritative textbooks, guidelines, and reviews supporting this reference entry. Verify reference intervals, critical limits, and reflex criteria against institutional protocols and current guideline editions.
Textbooks
- McPherson RA, Pincus MR. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Elsevier; 2021.
- Rodak BF, Carr JH. Rodak's Hematology: Clinical Principles and Applications. 6th ed. Elsevier; 2020.
- McKenzie SB, Williams JL. Clinical Laboratory Hematology. 4th ed. Pearson; 2022.
Professional Monographs
- Barnes PW, McFadden SL, Machin SJ, Doig K. Laboratory Hematology Practice. Wiley-Blackwell; 2012.
CLSI and Professional Guidelines
- Clinical and Laboratory Standards Institute. Reference Leukocyte (WBC) Differential Count (Proportional) and Evaluation of Instrumental Methods; Approved Standard. CLSI document H20-A2. CLSI; 2007.
- Clinical and Laboratory Standards Institute. Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory; Approved Standard. CLSI document EP28-A3c. CLSI; 2010.
- Clinical and Laboratory Standards Institute. Management of Critical- and Significant-Risk Results. CLSI guideline GP47-Ed1. CLSI; 2015.
WHO Publications
- World Health Organization Classification of Haematolymphoid Tumours. 5th ed. Lyon: International Agency for Research on Cancer; 2022.
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