Overview
Standardized terminology for platelet laboratory reporting and interpretation.
Classification
| Term | Definition | Association examples (not exclusive) |
|---|---|---|
| Thrombocytopenia | PLT below report interval | Production, destruction, sequestration, artifact |
| Thrombocytosis | PLT above report interval | Reactive, spurious, clonal among others |
| MPV elevated | Average platelet size increased | Recovery, destruction, storage effect |
| Platelet clump | Aggregated platelets on smear | EDTA pseudothrombocytopenia classic |
| Giant platelet | Platelet larger than normal RBC | Bernard-Soulier, ITP recovery, MDS among others |
| Hypogranular platelet | Reduced granules on smear | MDS, storage, activation among others |
Morphologic Features
Wright-Giemsa monolayer review at 100× oil for platelet detail.
Laboratory Characteristics
- EDTA standard for CBC PLT; citrate for verification per SOP
Reference Intervals
Qualitative morphology, quantitative count uses report intervals.
Clinical and Laboratory Significance
Terms support pattern comments, not disease labels alone.
Differential Considerations
Never assign one finding to one disease exclusively.
Comparison Tables
Classification Frameworks
Laboratory Notes
- Interpret results against the performing laboratory reference intervals and current SOP.
References
Authoritative textbooks, guidelines, and reviews supporting this reference entry. Verify reference intervals, critical limits, and reflex criteria against institutional protocols and current guideline editions.
Textbooks
- McPherson RA, Pincus MR. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Elsevier; 2021.
- Rodak BF, Carr JH. Rodak's Hematology: Clinical Principles and Applications. 6th ed. Elsevier; 2020.
- McKenzie SB, Williams JL. Clinical Laboratory Hematology. 4th ed. Pearson; 2022.
- Bain BJ. Blood Cells: A Practical Guide. 5th ed. Wiley-Blackwell; 2015.
CLSI and Professional Guidelines
- Clinical and Laboratory Standards Institute. Reference and Selected Performance Standards for the Automated Complete Blood Cell Count (CBC). CLSI document H26-A2. CLSI; 2010.
- Clinical and Laboratory Standards Institute. Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory; Approved Standard. CLSI document EP28-A3c. CLSI; 2010.
- Clinical and Laboratory Standards Institute. Management of Critical- and Significant-Risk Results. CLSI guideline GP47-Ed1. CLSI; 2015.
- Clinical and Laboratory Standards Institute. Collection, Transport, and Processing of Blood Specimens for Testing Plasma-Based Coagulation Assays and Molecular Hemostasis Assays; Approved Guideline. CLSI document H21-A5. CLSI; 2017.
Frequently Asked Questions
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