Overview
Lineage axis for malignancy workup.
Classification
| Clue | Myeloid among associations | Lymphoid among associations |
|---|---|---|
| Rods/inclusions | Auer rods | Absent |
| Typical blast size | Larger, granular | Smaller, agranular |
| Mature pattern | Granulocytic proliferation | Lymphocytosis, smudge cells |
| Confirmatory | MPO+, CD13/33 among panels | CD19/CD3 among panels |
Morphologic Features
Laboratory Characteristics
Reference Intervals
Clinical and Laboratory Significance
Differential Considerations
Comparison Tables
Classification Frameworks
Laboratory Notes
References
Authoritative textbooks, guidelines, and reviews supporting this reference entry. Verify reference intervals, critical limits, and reflex criteria against institutional protocols and current guideline editions.
Textbooks
- Arber DA, Orazi A, Hasserjian RP, et al. Atlas of Diagnostic Hematology. 4th ed. Elsevier; 2023.
- Bain BJ. Blood Cells: A Practical Guide. 6th ed. Wiley-Blackwell; 2022.
- Rodak BF, Carr JH. Rodak's Hematology: Clinical Principles and Applications. 6th ed. Elsevier; 2020.
- McKenzie SB, Williams JL. Clinical Laboratory Hematology. 4th ed. Pearson; 2022.
- Hoffbrand AV, Moss PAH, Pettit JE. Essential Haematology. 8th ed. Wiley-Blackwell; 2019.
CLSI and Professional Guidelines
- International Consensus Classification of Myeloid Neoplasms and Acute Leukemias (ICC). Blood. 2022;140(11):1200–1228.
WHO Publications
- World Health Organization. WHO Classification of Haematolymphoid Tumours. 5th ed. Volume 11. Lyon: IARC Press; 2024.
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