Overview
Classification overview for Module 12 . Academy teaches algorithms; Library owns lookup tables.
Classification
| Category | Representative entities | Screening PB pattern | Key confirmatory tests |
|---|---|---|---|
| Acute myeloid | AML among entities | Blasts, cytopenias, Auer rods among clues | Marrow, flow, cytogenetics, molecular panel |
| Acute lymphoid | ALL among entities | Lymphoblasts, variable WBC | Flow (B/T markers), marrow, genetics |
| Chronic myeloid | CML among entities | Leukocytosis, basophilia, left shift | BCR-ABL1, cytogenetics |
| Chronic lymphoid | CLL among entities | Sustained ALC, smudge cells | Flow clonal B-cell panel |
| MDS | MDS among entities | Cytopenias, dysplasia | Marrow dysplasia, blasts %, cytogenetics |
| MPN | PV, ET, PMF among entities | Elevated Hb/Hct, PLT, or WBC | JAK2/CALR/MPL, marrow |
| Plasma cell | Myeloma spectrum among entities | Rouleaux, anemia, ↑ total protein | SPEP/IFE, FLC, marrow plasma cells |
Morphologic Features
See malignancy-pb-bm-patterns for finding-level lookup.
Laboratory Characteristics
- WHO/ICC edition-specific thresholds are hematopathology domain
Reference Intervals
Institutional blast critical values, verify locally.
Clinical and Laboratory Significance
Distinguish screening suspicion from confirmed classification.
Differential Considerations
Reactive patterns far more common . Module 6 framework.
Comparison Tables
Classification Frameworks
Refer to WHO Haematolymphoid Tumours (5th ed.) and ICC for authoritative entity definitions . LabPedia summarizes laboratory correlates only.
Laboratory Notes
- Compare related entries in Laboratory Library for side-by-side differentiators.
References
Authoritative textbooks, guidelines, and reviews supporting this reference entry. Verify reference intervals, critical limits, and reflex criteria against institutional protocols and current guideline editions.
Textbooks
- Arber DA, Orazi A, Hasserjian RP, et al. Atlas of Diagnostic Hematology. 4th ed. Elsevier; 2023.
- Bain BJ. Blood Cells: A Practical Guide. 6th ed. Wiley-Blackwell; 2022.
- Rodak BF, Carr JH. Rodak's Hematology: Clinical Principles and Applications. 6th ed. Elsevier; 2020.
- McKenzie SB, Williams JL. Clinical Laboratory Hematology. 4th ed. Pearson; 2022.
- Hoffbrand AV, Moss PAH, Pettit JE. Essential Haematology. 8th ed. Wiley-Blackwell; 2019.
CLSI and Professional Guidelines
- International Consensus Classification of Myeloid Neoplasms and Acute Leukemias (ICC). Blood. 2022;140(11):1200–1228.
WHO Publications
- World Health Organization. WHO Classification of Haematolymphoid Tumours. 5th ed. Volume 11. Lyon: IARC Press; 2024.
Frequently Asked Questions
Common questions about using this Hematologic Malignancy . Classification Overview foundational topics Medical Laboratory Library reference in Medical Laboratory Science education.
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