Overview
Megaloblastic Anemia . Laboratory Lookup, laboratory pattern lookup. Patterns suggest associations; CBC/smear alone do not diagnose.
Classification
| Feature | Typical pattern | Confirmatory direction |
|---|---|---|
| RBC smear | Macro-ovalocytes | B₁₂/folate panel |
| WBC smear | Hypersegmentation | Cross-link neutrophils Academy |
| Chemistry | ↓ B₁₂ and/or ↓ folate | MMA for B₁₂ context |
Morphologic Features
Integrate smear with indices . Module 7 morphology lessons for term definitions.
Laboratory Characteristics
- Use institutional reference intervals and reflex algorithms.
Reference Intervals
No universal numeric thresholds, verify locally.
Clinical and Laboratory Significance
Hedged laboratory comments per institutional style guide.
Differential Considerations
See anemia-classification-comparison for side-by-side differentiators.
Comparison Tables
Classification Frameworks
Laboratory Notes
- Interpret anemia comments against the performing laboratory’s reference intervals and reflex algorithms.
- Integrate smear morphology with CBC indices before favoring a single etiology.
References
Authoritative textbooks, guidelines, and reviews supporting this reference entry. Verify reference intervals, critical limits, and reflex criteria against institutional protocols and current guideline editions.
Textbooks
- McPherson RA, Pincus MR. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Elsevier; 2021.
- Rodak BF, Carr JH. Rodak's Hematology: Clinical Principles and Applications. 6th ed. Elsevier; 2020.
- McKenzie SB, Williams JL. Clinical Laboratory Hematology. 4th ed. Pearson; 2022.
- Hoffbrand AV, Moss PAH, Pettit JE. Essential Haematology. 8th ed. Wiley-Blackwell; 2019.
- Bain BJ. Blood Cells: A Practical Guide. 5th ed. Wiley-Blackwell; 2015.
CLSI and Professional Guidelines
- Clinical and Laboratory Standards Institute. Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory; Approved Standard. CLSI document EP28-A3c. CLSI; 2010.
- Clinical and Laboratory Standards Institute. Reference and Selected Performance Standards for the Automated Complete Blood Cell Count (CBC). CLSI document H26-A2. CLSI; 2010.
WHO Publications
- World Health Organization. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. WHO/NMH/NHD/MNM/11.1. Geneva: WHO; 2011.
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